Journal article
Antibody responses to antigenic targets of recent exposure are associated with low-density parasitemia in controlled human plasmodium falciparuminfections
LL Van Den Hoogen, J Walk, T Oulton, IJ Reuling, L Reiling, JG Beeson, RL Coppel, SK Singh, SJ Draper, T Bousema, C Drakeley, R Sauerwein, KKA Tetteh
Frontiers in Microbiology | FRONTIERS MEDIA SA | Published : 2019
Open access
Abstract
The majority of malaria infections in low transmission settings remain undetectable by conventional diagnostics. A powerful model to identify antibody responses that allow accurate detection of recent exposure to low-density infections is controlled human malaria infection (CHMI) studies in which healthy volunteers are infected with the Plasmodium parasite. We aimed to evaluate antibody responses in malaria-naïve volunteers exposed to a single CHMI using a custom-made protein microarray. All participants developed a blood-stage infection with peak parasite densities up to 100 parasites/μl in the majority of participants (50/54), while the remaining four participants had peak densities betwee..
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Grants
Awarded by Wellcome Trust
Funding Acknowledgements
This work was supported by funding provided by The Global Good Fund I, LLC (www.globalgood.com) (KT) and the Wellcome Trust (Grant Number 091924). In addition, TB acknowledges funding from a VIDI fellowship from The Netherlands Organization for Scientific Research (NWO, Project Number 016.158.306). SD was a Jenner Investigator, a Lister Institute Research Prize Fellow and a Wellcome Trust Senior Fellow (Grant Number 106917/Z/15/Z). JB was supported by a Senior Research Fellowship (1077636) and Program Grant (1092789) from the National Health and Medical Research Council of Australia. RC acknowledges funding from the Australian National Health and Medical Research Council.